Reis and Abdo (2014) stated that with advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The effectiveness of phosphodiesterase type 5 inhibitors (PDE5i), together with their minimal side effects and ease of administration, revolutionized the treatment of erectile dysfunction. For women, testosterone administration is the principal treatment for hypoactive sexual desire disorder. These investigators evaluated the use of androgens in the treatment of a lack of libido in women, comparing 2 periods, ., before and after the advent of the PDE5i. These researchers also analyzed the risks and benefits of androgen administration. They searched the Latin-American and Caribbean Health Sciences Literature, Cochrane Library, Excerpta Medica, Scientific Electronic Library Online, and Medline (PubMed) databases using the search terms disfunção sexual feminina/female sexual dysfunction, desejo sexual hipoativo/female hypoactive sexual desire disorder, testosterona/testosterone, terapia androgênica em mulheres/androgen therapy in women, and sexualidade/sexuality as well as combinations thereof. They selected articles written in English, Portuguese, or Spanish. The authors concluded that after the advent of PDE5i, there was a significant increase in the number of studies aimed at evaluating the use of testosterone in women with hypoactive sexual desire disorder. However, they stated that the risks and benefits of testosterone administration have yet to be clarified.
For the off-season athlete there is no anabolic steroid more important or beneficial than testosterone. High levels of testosterone will promote significant increases in lean muscle mass and strength. This is assuming that the individual is consuming adequate calories. Compounds like Testosterone Propionate are not magical, you will still need to feed your body enough calories. During an off-season period of growth, this means total caloric intake will need to be slightly above maintenance. This will, unfortunately, promote body fat gain. However, the key to a successful off-season is gaining lean tissue while minimizing body fat gain to the fullest extent possible. By supplementing with Testosterone Propionate you will be able to achieve this more efficiently. High testosterone levels will promote a stronger metabolic rate. This is not a license to eat like there’s no end in sight, but you should be able to make better use of your calories.
Other significant adverse effects of testosterone supplementation include acceleration of pre-existing prostate cancer growth in individuals who have undergone androgen deprivation; increased hematocrit , which can require venipuncture in order to treat; and, exacerbation of sleep apnea .  Adverse effects may also include minor side-effects such as acne and oily skin, as well as, significant hair loss and/or thinning of the hair, which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia , such as finasteride .  Exogenous testosterone may also cause suppression of spermatogenesis , leading to, in some cases, infertility.  It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor PSA and hematocrit levels closely during therapy.