This Food Additives Status List, formerly called Appendix A of the Investigations Operations Manual (IOM), organizes additives found in many parts of 21 CFR into one alphabetized list. Additives included are those specified in the regulations promulgated under the FD&C Act, under Sections 401 (Food Standards), and 409 (Food Additives). The Food Additives Status List includes short notations on use limitations for each additive. For complete information on its use limitations, refer to the specific regulation for each substance. New regulations and revisions are published in current issues of the Federal Register as promulgated. Also refer to the Food Ingredient and Packaging inventories in the Foods section of the FDA web site to review several FDA databases of additive categories. For example, the EAFUS list (Everything Added to Food in the United States), is a helpful reference within the limitations described at the beginning of the database.
There is considerable controversy over the earliest age at which it is clinically, morally, and legally safe to use GnRH analogues, and for how long. The sixth edition of the World Professional Association for Transgender Health 's Standards of Care permit it from Tanner stage 2 but do not allow the addition of hormones until age 16, which could be five or more years later. Sex steroids have important functions in addition to their role in puberty, and some skeletal changes (such as increased height) that may be considered masculine are not hindered by GnRH analogues.