Saw palmetto extract may decrease the effectiveness of estrogen products by reducing estrogen levels in the body via its antiestrogenic effects.  It can interfere with the use of birth control pills that contain estrogen as an active ingredient. As a result, it is recommended that an additional form of birth control, such as a condom, be used to prevent pregnancy in patients taking birth control pills with saw palmetto extract. In addition, saw palmetto extract can also interfere with hormone replacement therapy by reducing the effectiveness of estrogen pills. The combination of saw palmetto extract with estrogen products should be used with caution. 
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Winstrol is hepatotoxic, and because of this, it should be used at the lowest effective dose for the shortest possible cycle. What’s more, you should consider using a supplement designed to provide some additional protection. Milk thistle is a highly recommended option; studies suggest it can provide an effective layer of protection when it is used for the entire length of your cycle. There are some other supplements on the market, such as Liver Care, which are blends of natural ingredients that have been shown to work together to prevent liver toxicity.