In Australia and New Zealand, orlistat is currently [update] available over-the-counter in 120 mg size (84 capsules to the pack). Initially available only with a prescription, it was reclassified as a " Pharmacist Only Medicine " in October 2003. In 2007 the Committee decided to keep orlistat as a Schedule 3 drug , but withdrew its authorization of direct-to-consumer Xenical advertising, stating this "increased pressure on pharmacists to provide orlistat to consumers...this in turn had the potential to result in inappropriate patterns of use".  Xenical has recently [ when? ] began being advertised direct-to-customers again.
In 2014 Geron Corporation received permission to resume a trial of its drug imetelstat for myelofibrosis after addressing FDA concerns over liver toxicity.   Geron licensee Merck had approval of an IND for one vaccine type. [ citation needed ] Imetelstat (GRN163L) binds directly to the telomerase's RNA template. One 2015 study reported that Imetelstat caused partial or complete remission in seven of 33 patients, while a second reported that it decreased blood platelet levels in all 18 study patients with essential thrombocythemia , a disorder in which the body overproduces blood platelets, increasing the risk of blood clots.